Effects of Chronic Prenatal Adversities on the Adult Response to a Social Stressor
Bibliographic record
Abstract
It was hypothesized that prenatal stressor effects persist into adulthood and would be particularly notable following re-exposure to an adult stressor.Pregnant mice were stressed for 12 days and adult offspring underwent a social stressor.Following the adult treatment, exploratory and social behaviour, and plasma corticosterone (CORT) levels were observed in addition to cytokine, corticotropin releasing hormone (CRH), and CRH receptor messenger RNA (mRNA) expression in the prefrontal cortex (PFC).Increased and decreased anxiety-like behaviour was observed in males and females, respectively.Also, elevated CORT was detected in prenatally stressed males and females while increased pro-inflammatory cytokines, CRH, and CRH receptor 1 (CRHR1) in the PFC were mainly observed in prenatally stressed females.These findings suggest gender dimorphic effects of maternal stress on behaviour and PFC cytokine, CRH, and CRHR1 expression that may impair stress and emotional regulation in the offspring.iii
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".