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Record W2921244230 · doi:10.21307/ajon-2017-014

The Brain on Fire: A Case Study on Anti-NMDA Receptor Encephalitis

2019· article· en· W2921244230 on OpenAlexaff
Grissel B Crasto

Bibliographic record

VenueAustralasian Journal of Neuroscience · 2019
Typearticle
Languageen
FieldMedicine
TopicAutoimmune Neurological Disorders and Treatments
Canadian institutionsToronto Western Hospital
Fundersnot available
KeywordsAnti-NMDA receptor encephalitisEncephalitisPsychosisNMDA receptorMedicinePopulationIntensive care medicineNeurosciencePsychologyPsychiatryReceptorImmunologyInternal medicineVirusEnvironmental health

Abstract

fetched live from OpenAlex

Abstract Anti-NMDA receptor encephalitis is a rare disease that occurs when antibodies produced by the body’s own immune system attack the N-methyl-d-aspartate (NMDA) receptors in the brain (Dalmau, 2016). For a relatively rare condition, one academic hospital in an urban centre noted four cases of anti-NMDA receptor encephalitis in one single year. Patients develop a multistage condition that progresses from psychosis, memory deficits, seizures, respiratory difficulties, abnormal catatonic movements and language disintegration into a state of unresponsiveness (Dalmau, Lancaster, Hernandez, Rosenfeld and Gordon, 2011). This case study will focus on the pathologies and medical journeys of three female patients diagnosed with anti-N-NMDA receptor encephalitis at this hospital. This paper will discuss the presentations of each of the cases and the individualized nursing care plans developed to address the needs of this patient population. More specifically, it will highlight the importance of ensuring patient and staff safety in the development of these care plans. The need for implementing ongoing evaluations of these nursing care plans to address the developing needs of patients as they proceed through the diverse and complex phases of the condition will also be discussed.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Case report · Consensus signal: Case report
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score0.025

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0040.003
Science and technology studies0.0070.002
Scholarly communication0.0020.004
Open science0.0020.003
Research integrity0.0060.007
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.315
Teacher spread0.282 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designCase report
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2019
Admission routes1
Has abstractyes

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