Abstract P036: Association Between Circulating Galectin-3 and Arterial Stiffness in the Atherosclerosis Risk in Communities Study
Bibliographic record
Abstract
Introduction: Galectin-3 (gal-3) is a B-galactoside-binding lectin and is associated with increased risk of heart failure and other adverse cardiovascular outcomes. Circulating gal-3 has been implicated in promoting tissue fibrosis, leading to vascular remodeling and resultant arterial stiffening. Hypothesis: Plasma gal-3 levels will be associated with central arterial stiffness in a community-based population. Methods: We conducted a cross-sectional analysis of 4,073 participants from the Atherosclerosis Risk in Communities (ARIC) Study who attended visit 5 (2011-2013), with a mean age of 75.1±5.0 years. Central arterial stiffness was measured by carotid-femoral pulse wave velocity (cfPWV). Association between gal-3 and arterial stiffness was assessed using multivariable linear regression models with gal-3 (log transformed) and adjustment first for age, sex, race-center, heart rate, current smoking, mean arterial pressure and use of anti-hypertensive medication (model 1), then for model 1 plus body mass index (BMI), diabetes, hypertension, LDL cholesterol and estimated glomerular filtration rate (eGFR) (model 2). Results: The median gal-3 concentration was 16.5 ng/mL (p25, p75: 13.8, 19.8) and mean cfPWV was 1163 (SD, 303) cm/s. Higher gal-3 concentrations corresponded with higher mean cfPWV and central pulse pressure (p-trends <0.001). Higher gal-3 levels were also associated with higher BMI, diabetes, hypertension, LDL cholesterol, cholesterol lowering medication use, prevalent coronary artery disease, and lower eGFR. In regression analysis, gal-3 was significantly associated with cfPWV in model 1 (ß=46.0; 95% CI 15.4-76.6, per natural log higher gal-3, p=0.003). Further adjustment in model 2 strongly attenuated the association and the coefficient was no longer significant (ß=25.0; 95% CI -8.2-58.2, per natural log increase in gal-3, p=0.14). Conclusions: Higher levels of gal-3, a known promoter of tissue fibrosis, were associated with greater central arterial stiffness. In addition, circulating gal-3 levels were also associated with many traditional risk factors such as BMI, diabetes, hypertension and eGFR; adjustment for these factors attenuated the association of gal-3 with arterial stiffness measures, suggesting mediation of the gal-3 association.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".