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Record W2921604361 · doi:10.1186/s13195-019-0476-1

Lewy Body Dementia Association’s Research Centers of Excellence Program: Inaugural Meeting Proceedings

2019· review· en· W2921604361 on OpenAlexfundno aff
Bethany L. Peterson, Melissa J. Armstrong, Douglas Galasko, James E. Galvin, Jennifer G. Goldman, David J. Irwin, Henry L. Paulson, Daniel Kaufer, James B. Leverenz, Angela Lunde, Ian G. McKeith, Andrew Siderowf, Angela Taylor, Katherine Amodeo, Matthew J. Barrett, Kimiko Domoto‐Reilly, John E. Duda, Stephen N. Gomperts, Neill R. Graff‐Radford, Samantha K. Holden, Lawrence S. Honig, Daniel E. Huddleston, Carol F. Lippa, Irene Litvan, Carol A. Manning, Karen Marder, Charbel Moussa, Chiadi U. Onyike, Fernando Pagán, Alexander Pantelyat, Victoria S. Pelak, Kathleen L. Poston, Joseph F. Quinn, Irene Hegeman Richard, Liana S. Rosenthal, Marwan N. Sabbagh, Douglas W. Scharre, Sharon Sha, Holly A. Shill, Yasar Torres‐Yaghi, Tina Christie, Todd Graham, Ian Richards, Mike Koehler, Bradley F. Boeve

Bibliographic record

VenueAlzheimer s Research & Therapy · 2019
Typereview
Languageen
FieldEconomics, Econometrics and Finance
TopicHealth Systems, Economic Evaluations, Quality of Life
Canadian institutionsnot available
FundersNational Institute on AgingCanadian Institutes of Health ResearchAvid RadiopharmaceuticalsParkinsonfondenJohns Hopkins UniversityUniversity of California, San DiegoAstraZenecaGenentechHealth Resources and Services AdministrationUniversity of Southern CaliforniaEisaiNational Institute for Health and Care ResearchMayo ClinicTauRx PharmaceuticalsAdministration for Community LivingScheme for Promotion of Academic and Research CollaborationLittle Family FoundationGordon and Marilyn Macklin FoundationProthenaAcorda TherapeuticsIonis PharmaceuticalsMichael J. Fox Foundation for Parkinson's ResearchParkinson's FoundationH. Lundbeck A/SLewy Body Dementia AssociationNational Institute of Neurological Disorders and StrokeSunovionAllerganF. Hoffmann-La RocheRush UniversityDemensförbundetGeorgetown UniversityGeorgia Research AllianceGrifolsTau ConsortiumEmerald FoundationCurePSPUniversity of PennsylvaniaBristol-Myers SquibbTeva Pharmaceutical IndustriesCHDI FoundationInternational Parkinson and Movement Disorder SocietyNational Ataxia FoundationBiogenU.S. Department of DefenseEli Lilly and CompanyBrightFocus FoundationSanofiAlzheimer's AssociationNational Institutes of HealthAssociation for Frontotemporal DegenerationJanssen PharmaceuticalsParkinson Vereniging
KeywordsDementia with Lewy bodiesLewy bodyExcellenceDementiaClinical trialMedicineGerontologyFamily medicineDiseasePolitical sciencePathology

Abstract

fetched live from OpenAlex

The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator's meeting was held on December 14, 2017, in New Orleans. The program was established to increase patient access to clinical experts on Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), and to create a clinical trials-ready network. Four working groups (WG) were created to pursue the LBDA RCOE aims: (1) increase access to high-quality clinical care, (2) increase access to support for people living with LBD and their caregivers, (3) increase knowledge of LBD among medical and allied (or other) professionals, and (4) create infrastructure for a clinical trials-ready network as well as resources to advance the study of new therapeutics.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.115
metaresearch head score (Gemma)0.006
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.571
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.1150.006
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0040.001
Bibliometrics0.0020.002
Science and technology studies0.0010.000
Scholarly communication0.0000.001
Open science0.0020.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0010.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.800
GPT teacher head0.602
Teacher spread0.198 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations11
Published2019
Admission routes1
Has abstractyes

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