Abstract 426: Atherosclerotic Risk Factors Correlate with Carotid Intimal Media Thickness in Participants of the Childhood Obesity Study in South Texas: Preliminary Results
Bibliographic record
Abstract
Rationale: The prevalence of childhood and adolescent obesity is increasing in the United States, where one-third of children and adolescents are affected. This is especially true in the Hispanic population. It is well known that obesity is positively associated with increased atherosclerosis, the primary cause of cardiovascular disease (CVD). Our study objective was to determine whether carotid intima-media thickness (CIMT) is associated with the severity of obesity and cardiovascular risk factors in obese Hispanic adolescents in San Antonio, Texas. We present for the first time, preliminary results for an on-going, Childhood Obesity Study at The Children’s Hospital of San Antonio, where obese children in South Texas are referred for weight management. Methods: We present data for 36 obese subjects (males= 21) with an average % of the CDC 95 th BMI percentile of 139 at baseline (first clinic visit). The mean age was 15 + 1 years. We assessed cardiovascular risk factors and measured CIMT using B-mode ultrasonography on the left and right carotid arteries. For each patient, we calculated mean CIMT for carotid internal artery, common carotid artery, and carotid bulb, and the mean for all the CIMT measurements. Results: There were no age-sex differences in BMI, plasma LDL-C, high sensitivity C-reactive protein (hs-CRP) and CIMT. The mean CIMT for the common carotid artery (CIMT-CCA), carotid internal artery (CIMT-CIA), and carotid bulb (CIMT-CB) were 0.50±0.12, 0.43±0.22, and 0.60±0.29 mm respectively. BMI correlated with CIMT-CIA (p= 0.012) and CIMT-CB (p= 0.002). The correlation remained significant with the means of all the CIMT measurements (p= 0.002). Plasma hs-CRP and LDL-C concentrations correlated with CIMT-CIA (p= 0.045) and the means for all CIMT measurements (p= 0.027). We did not observe significant correlations with CIMT for the common carotid artery. Conclusion: Cardiovascular risk factors assessed in adolescents who are obese correlate with CIMT, a surrogate for atherosclerotic burden, suggesting that these obese adolescents have early onset atherosclerosis. Our results are preliminary and should be interpreted cautiously.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".