A24 RELATION BETWEEN VITAMIN D STATUS AND IBD-RELATED HOSPITALISATION IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE TREATED WITH IMMUNOSUPPRESSANT OR BIOLOGICAL AGENTS

Vitamin D deficiency is known to be a frequent finding in patients with inflammatory bowel disease (IBD) such as Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBDU). Several studies have shown an association between low vitamin D levels and high disease activity, which translates into a lower quality of life. The aim of this study was to assess the relation between vitamin D insufficiency (50–74 nmol/L) or deficiency (< 50 nmol/L) and the disease activity in children with IBD as measured by the hospitalisation rate. All patients with CD, UC or IBDU identified in our IBD database were included if they met all the following criteria: (1) diagnosed between January 2011 and June 2018, (2) aged 5 to 18 at diagnosis, (3) treated with immunosupressants or biologics and (4) had at least one vitamin D measurement. Baseline vitamin D blood level at diagnosis was defined as a measurement that occurred between 90 days before and 30 days after diagnosis. Association between low vitamin D levels and the risk of subsequent hospitalisations was analysed with Statistical Analysis Software (SAS). Overall, 202 (95 females) patients, with a mean (SD) age of 13.1 (± 3.1) years old at diagnosis, met the inclusion criteria of this study. Of these, 149 (73.8%) were diagnosed with CD, 43 (21.3%) with UC and 10 (4.9%) with IBDU. The mean (SD) follow-up duration was 36.2 (± 21.4) months. A total of 116 (57,4%) patients were hospitalized at diagnosis and 92 (45.5%) had at least one IBD-related hospitalisation after diagnosis. Baseline vitamin D levels were available for 130 children, with a mean (SD) of 53.6 (± 20.8) nmol/L for patients who were hospitalized at diagnosis and 62.6 (± 20.5) nmol/L for those who were not hospitalized (P=0.020). Patients with vitamin D deficiency were more likely to be hospitalized at diagnosis [odds ratio 2.6 (95% CI: 1.1 – 5.6, P=0.024)]. However, the hazard ratio for subsequent hospitalisation in patients with vitamin D deficiency at diagnosis was 0.9 (95% CI: 0.5 – 1.5, P=0.672). Vitamin D deficiency is associated with a higher risk of IBD-related hospitalisation at diagnosis. Whether vitamin D deficiency is a true risk factor for severe disease remains to be established. These results support the need for monitoring vitamin D levels in patients with IBD. None

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