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Record W2922285707 · doi:10.1002/9783527628698.hgc126

Key Metrics to Inform Chemical Synthesis Route Design

2018· other· en· W2922285707 on OpenAlexaff
John Andraos, Andrei Hent

Bibliographic record

Venuenot available
Typeother
Languageen
FieldEnvironmental Science
TopicChemistry and Chemical Engineering
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsKey (lock)Process (computing)Efficient energy useHazardComputer scienceEngineeringProcess engineeringRisk analysis (engineering)Process managementBusinessChemistryOrganic chemistryComputer security

Abstract

fetched live from OpenAlex

The sections in this article are Introduction Material Efficiency Analysis for Synthesis Plans Case Study I : Bortezomib Millennium Pharmaceuticals' Process Pharma‐Sintez Process Material Efficiency – Local and Express Synthesis Strategy for Future Optimization Summary Case Study II : Aspirin Reaction Network Material Efficiency Environmental and Safety–Hazard Impact Input Energy Case I Case II Case III Case IV Case V Case VI Concluding Remarks and Outlook for Improvements

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.338
Threshold uncertainty score0.992

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0820.009

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.199
Teacher spread0.188 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2018
Admission routes1
Has abstractyes

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