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Record W2922437152 · doi:10.5206/uwomj.v85i1.4233

The digital pill

2016· article· en· W2922437152 on OpenAlexvenueno aff
Steven Wong, Victoria Chan

Bibliographic record

VenueUniversity of Western Ontario Medical Journal · 2016
Typearticle
Languageen
FieldMedicine
TopicMedication Adherence and Compliance
Canadian institutionsnot available
Fundersnot available
KeywordsPillMedicineModalitiesMedical prescriptionInternet privacyCompliance (psychology)Food and drug administrationPsychiatryIntensive care medicineMedical emergencyPharmacologyPsychologyComputer science

Abstract

fetched live from OpenAlex

Compliance with prescription medication regimens is poor in patients who suffer from chronic conditions as well as from diseases that affect public health. It is thought that improving medication adherence can have a profound effect on patient health, though medication compliance remains a problem despite the availability of many modalities. Recently, digitalizing medication adherence was made possible by Proteus Digital Health, Inc using an ingestible sensor that emits an electric field upon digestion. This signal is detected by an externally worn adhesive monitor, which records the time at which the signal is received, along with other biometric markers such as heart rate. This system is currently under United States Food and Drug Administration (FDA) review for use in a combination pill that also contains aripiprazole, a partial dopamine agonist used for the treatment of certain serious psychiatric conditions. Digitalizing medication adherence can have tremendous applications in all fields of medicine, though issues of drug costs, patient privacy, and patient autonomy may need to be addressed.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.679
Threshold uncertainty score0.997

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.228
Teacher spread0.209 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2016
Admission routes1
Has abstractyes

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