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Record W2923581560 · doi:10.1161/atvbaha.119.312430

Legumain in Pulmonary Arterial Hypertension

2019· letter· en· W2923581560 on OpenAlexafffund
Lisette Hilton, Mark L. Ormiston

Bibliographic record

VenueArteriosclerosis Thrombosis and Vascular Biology · 2019
Typeletter
Languageen
FieldMedicine
TopicPulmonary Hypertension Research and Treatments
Canadian institutionsQueen's University
FundersCanadian Institutes of Health Research
KeywordsCardiologyMedicinePulmonary hypertensionInternal medicineBusiness

Abstract

fetched live from OpenAlex

Legumain and TGF-β: Active Player in PAH 537which remains the preclinical gold standard for this disease. 17Can legumain inhibitors pass this hurdle and join other protease inhibitors like Elafin 18 in clinical trials for PAH?Should this be the case, what evidence is there to suggest that such an approach will succeed where other anti-inflammatory strategies have failed?Only time will tell.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: none
Teacher disagreement score0.023
Threshold uncertainty score0.021

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.009
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.000
Science and technology studies0.0020.001
Scholarly communication0.0020.002
Open science0.0010.001
Research integrity0.0230.020
Insufficient payload (model declined to judge)0.0050.005

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.057
GPT teacher head0.293
Teacher spread0.236 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEditorial

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2019
Admission routes2
Has abstractyes

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