MISTIE III: a big step in the right direction
Bibliographic record
Abstract
On February 7 the results of phase 3 of the Minimally Invasive Surgery Plus rt-PA for Intracerebral Hemorrhage Evacuation (MISTIE III) trial were published in the Lancet .1 The trial did not reach its primary endpoint of improved functional outcome at 1 year. It did, however, generate a wealth of high-quality data that provide invaluable insight into this devastating disease. MISTIE III was an open-label blinded endpoint trial performed at 78 hospitals in the USA, Canada, Europe, Australia, and Asia that randomized (1:1) 506 patients to minimally invasive surgery or standard medical treatment. Eligible patients presented with a hematoma measuring ≥30 mL, a National Institutes of Health Stroke Scale score ≥6, good baseline status, a CT angiogram negative for an underlying lesion, and a repeat CT demonstrating clot volume stability for at least 6 hours. Average time to randomization was 47 hours in the surgical group and 46 hours in the medical group. The average time to surgery was 58.3 hours with an average procedural duration of 1 hour. Clinical deterioration led to craniotomy or craniectomy in four patients …
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.011 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.005 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.006 | 0.010 |
| Insufficient payload (model declined to judge) | 0.031 | 0.013 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".