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Record W2924885210 · doi:10.1071/ma19006

Phage research in ‘organ-on-chip’ devices

2019· article· en· W2924885210 on OpenAlexaff
Wai Hoe Chin, Jeremy J. Barr

Bibliographic record

VenueMicrobiology Australia · 2019
Typearticle
Languageen
FieldEngineering
TopicInnovative Microfluidic and Catalytic Techniques Innovation
Canadian institutionsCarbon Engineering (Canada)
FundersNational Health and Medical Research CouncilMonash UniversityAustralian National Fabrication Facility
KeywordsBacteriophagePhage displayTranslational researchBiotechnologyComputational biologyComputer scienceEngineeringBiologyBiochemical engineeringNanotechnologyGeneticsMaterials science

Abstract

fetched live from OpenAlex

The use of 'organ-on-chip' devices in microbiology research presents enormous opportunities for fundamental and translational research. Yet these approaches have not been widely embraced by the microbiology field. This is particularly evident with bacteriophage (phage) research applications. Traditionally phage research has been a nearly adopter of experimental techniques and approaches, having catalysed research in biotechnology, environmental biology, sequencing, and synthetic biology. Here we discuss some of the opportunities that organ-on-chip devices present to both phage and microbiology research, and provide a 'how to' guide for researchers interested in utilising this approach.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.002
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0020.002
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.061
GPT teacher head0.338
Teacher spread0.277 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7
Published2019
Admission routes1
Has abstractyes

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