Vitamin D is inversely related to parathyroid hormone in newborn Canadian infants
Bibliographic record
Abstract
Concentrations of 25(OH)D in the order of 75 nmol/L associated with a plateau in PTH are widely accepted as a target for defining optimal vitamin D status in adults and adolescents. The primary objective of this study was to examine the relationship between serum 25(OH)D and PTH from infant cord blood samples. Cord blood samples from 64 infants were measured for 25(OH)D (Octeia ELISA, Immunodiagnostic systems Ltd, UK) and PTH (Human Bioactive PTH 1–84 ELISA, Immutopics, USA). PTH and 25OHD were inversely correlated using Pearson analysis (r=−0.31 p=0.007, n=62) (Figure one). Infants with 25(OH)D ≤30 nmol/L had PTH values that were significantly higher than those with 25(OH)D 30–50 nmol/L (p<0.05) and ≥50 nmol/L (p<0.01) using ANOVA and Tukey's tests. The data suggests a plateau in PTH at [25(OH)D] 75 nmol/L, but requires further statistical modeling using a larger sample of concentrations above 75 nmol/L. Finding an optimal target for vitamin D status will not only aid in diagnostics but will assist current research on vitamin D supplementation levels for breastfed infants. Research was funded by Canadian Institute of Health Research
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".