Volatile Leaf Constituents and Anticancer Activity of <i>Bursera Simaruba</i> (L.) Sarg. Essential Oil
Why this work is in the frame
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Bibliographic record
Abstract
Leaf volatile components of Bursera simaruba (L.) Sarg., a native tree from tropical America used in traditional medicine, were extracted by hydrodistillation. The essential oil was analyzed by GC-MS. We have identified 38 compounds in this oil, of which limonene (46.7%), β-caryophyllene (14.7%), α-humulene (13.2%) and germacrene D (7.6%) are the major components. The anticancer activity of the essential oil was tested on human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line, DLD-1. B. simaruba leaf essential oil was found to be active against both tumor cell lines, with a GI 50 of 42 ± 2 μg/mL for A-549 and 48 ± 2 μg/mL for DLD-1. The evaluation of the cytotoxic properties of the major constituents of the oil indicates that α-humulene is possibly responsible for this activity.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it