Protein complex detection based on flower pollination mechanism in multi-relation reconstructed dynamic protein networks
Bibliographic record
Abstract
BACKGROUND: Detecting protein complex in protein-protein interaction (PPI) networks plays a significant part in bioinformatics field. It enables us to obtain the better understanding for the structures and characteristics of biological systems. METHODS: In this study, we present a novel algorithm, named Improved Flower Pollination Algorithm (IFPA), to identify protein complexes in multi-relation reconstructed dynamic PPI networks. Specifically, we first introduce a concept called co-essentiality, which considers the protein essentiality to search essential interactions, Then, we devise the multi-relation reconstructed dynamic PPI networks (MRDPNs) and discover the potential cores of protein complexes in MRDPNs. Finally, an IFPA algorithm is put forward based on the flower pollination mechanism to generate protein complexes by simulating the process of pollen find the optimal pollination plants, namely, attach the peripheries to the corresponding cores. RESULTS: The experimental results on three different datasets (DIP, MIPS and Krogan) show that our IFPA algorithm is more superior to some representative methods in the prediction of protein complexes. CONCLUSIONS: Our proposed IFPA algorithm is powerful in protein complex detection by building multi-relation reconstructed dynamic protein networks and using improved flower pollination algorithm. The experimental results indicate that our IFPA algorithm can obtain better performance than other methods.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".