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Record W2933308068 · doi:10.1007/s00401-019-01999-w

ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD

2019· article· en· W2933308068 on OpenAlexaff
Stephen Moore, Eric Alsop, Ileana Lorenzini, Alexander Starr, Benjamin E. Rabichow, Emily Méndez, Jennifer L. Levy, Camelia Burciu, Rebecca Reiman, Jeannie Chew, Véronique Belzil, Dennis W. Dickson, Janice Robertson, Kim A. Staats, Justin K. Ichida, Leonard Petrucelli, Kendall Van Keuren‐Jensen, Rita Sattler

Bibliographic record

VenueActa Neuropathologica · 2019
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicRNA regulation and disease
Canadian institutionsOccupational Cancer Research CentreUniversity of Toronto
FundersHarrington Discovery Institute, University HospitalsNational Institute of Neurological Disorders and StrokeTau ConsortiumNational Institutes of HealthBruno and Ilse Frick Foundation for Research on ALSBarrow Neurological FoundationDonald E. and Delia B. Baxter FoundationRobert Packard Center for ALS Research, Johns Hopkins UniversityAssociation for Frontotemporal DegenerationSouthern California Clinical and Translational Science InstituteNew York Stem Cell FoundationAlzheimer's Drug Discovery FoundationMuscular Dystrophy AssociationALS AssociationKeck School of Medicine of USCMayo ClinicTarget ALSJudith and Jean Pape Adams Charitable FoundationU.S. Department of Defense
KeywordsC9orf72RNA editingRNABiologyAmyotrophic lateral sclerosisRNA-binding proteinADARFrontotemporal dementiaInduced pluripotent stem cellCell biologyNeuroscienceGeneticsTrinucleotide repeat expansionGeneMedicinePathologyEmbryonic stem cell

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.901
Threshold uncertainty score0.421

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.227
Teacher spread0.219 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations70
Published2019
Admission routes1
Has abstractno

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