A MONOLITHIC MICRO DEVICE FOR GLUCOSE-RESPONSIVE INSULIN DELIVERY
Bibliographic record
Abstract
This paper presents a glucose-responsive device capable of modulating insulin diffusion rates according to changes in environmental glucose levels. A new glucose-responsive composite membrane was developed by crosslinking an albumin-based membrane with a micropatterned PDMS backbone. The membrane was made glucose responsive by the chemical immobilization of glucose oxidase (GOx) and catalase (CAT) along with embedded pH-responsive hydrogel nanoparticles. The nanoparticles act as intelligent 'nano-valves' in response to the enzymatic oxidation of glucose. The membrane responsiveness to glucose concentration was determined by testing the diffusion rates of bovine insulin at alternating glucose levels relevant to diabetic patients. Insulin diffusion across the membrane increases with increasing glucose concentration in the medium, and decreases when glucose is returned to lower levels. The glucose regulated profile of insulin release was also measured on proof-of-concept devices made with PDMS drug reservoirs and integrated glucose-responsive membrane.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".