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Record W2939780639 · doi:10.1152/ajpheart.00532.2017

MK5 haplodeficiency decreases collagen deposition and scar size during post-myocardial infarction wound repair

2019· article· en· W2939780639 on OpenAlexafffund
Sherin A. Nawaito, Pramod Sahadevan, Marie‐Élaine Clavet‐Lanthier, Philippe Pouliot, Fatiha Sahmi, Yanfen Shi, Marc‐Antoine Gillis, Frédéric Lesage, Matthias Gaestel, Martin G. Sirois, Angelo Calderone, Jean‐Claude Tardif, Bruce G. Allen

Bibliographic record

VenueAmerican Journal of Physiology-Heart and Circulatory Physiology · 2019
Typearticle
Languageen
FieldMedicine
TopicCardiac Fibrosis and Remodeling
Canadian institutionsUniversité de MontréalMontreal Heart Institute
FundersFondation Institut de Cardiologie de MontréalHeart and Stroke Foundation of Canada
KeywordsMedicineMyocardial infarctionInternal medicineFibrosisCardiology

Abstract

fetched live from OpenAlex

MK5/PRAK is a protein serine/threonine kinase activated by p38 MAPK and/or atypical MAPKs ERK3/4. MK5 haplodeficiency reduced infarct size, scar area, and scar collagen content post-myocardial infarction. Motility and proliferation were reduced in cultured MK5-null cardiac myofibroblasts.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.972
Threshold uncertainty score0.758

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.230
Teacher spread0.224 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations13
Published2019
Admission routes2
Has abstractyes

Explore more

Same venueAmerican Journal of Physiology-Heart and Circulatory PhysiologySame topicCardiac Fibrosis and RemodelingFrench-language works237,207