Neurodevelopmental Disorders and Autism in Valproic Acid Animal Models
Bibliographic record
Abstract
Xenobiotics and environmental toxicants cause the perturbations during embryogenesis and fetal development resulting in congenital malformations. The most vulnerable is the neural tube development due to the critical window period after the conception of the closure, cellular proliferation and differentiation. Neurodevelopmental disorders are multifactorial conditions encompassing wide categories and broad classification. Structural defects reveal as overt anatomical defects while the functional defects become apparent in the postnatal period of brain growth. Autism spectrum disorder [ASD] is an example of functional neurodevelopmental defect. The emphasis in this review is on the fact that neural tube defects are both structural and functional caused by the same teratogens such as valproic acid [VPA]. Valproic acid [VPA] has been discussed as a model teratogen for the development of neural tube defects and autism spectrum disorder [ASD].
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".