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PD60-11 A PHASE 3 STUDY TO EVALUATE THE SAFETY AND EFFICACY OF <sup>99M</sup> TC-MIP-1404 SPECT/CT IMAGING TO DETECT CLINICALLY SIGNIFICANT PROSTATE CANCER IN MEN WITH BIOPSY PROVEN LOW GRADE PROSTATE CANCER WHO ARE CANDIDATES FOR ACTIVE SURVEILLANCE (PROSPECT-AS)

2019· article· en· W2942262616 on OpenAlexaffabout
William J. Ellis, Bryan Donnelly, Michael A. Gorin, Frédéric Pouliot, Hao G. Nguyen, Peter R. Carroll, Douglas S. Scherr, Stephan Probst, Lawrence Saperstein, Neil Fleshner, Paul Maroni, Khushboo Shah, Nancy Stambler, Vincent A. DiPippo, Thomas Strack, Syed Mahmood, Jessica Jensen, Vivien Wong, Mohamad E. Allaf

Bibliographic record

VenueThe Journal of Urology · 2019
Typearticle
Languageen
FieldMedicine
TopicProstate Cancer Treatment and Research
Canadian institutionsAlberta Bible College
Fundersnot available
KeywordsMedicineProstate cancerNuclear medicineBiopsyRadiologyProstateCancerInternal medicine

Abstract

fetched live from OpenAlex

diagnosed were Gleason score 6.In addition, there were 4 (24%) cases of ASAP and 4 (24%) cases of HGPIN diagnosed.CONCLUSIONS: Second opinion review of a positive epigenetic assay in histopathological negative prostate biopsies resulted in a proportion of cases having the diagnosis of prostate cancer.These results suggest that epigenetic assays can be used to assist with prostate cancer diagnosis and may circumvent need for repeat prostate biopsy or have implications in surveillance strategies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.014

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.003
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.360
Teacher spread0.344 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2019
Admission routes2
Has abstractyes

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