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The brain's kryptonite: Overview of punctate white matter lesions in neonates

2019· review· en· W2942682324 on OpenAlexafffund
Annie L. A. Nguyen, Yang Ding, Sabrina Suffren, Irene Londoño, David Luck, Gregory A. Lodygensky

Bibliographic record

VenueInternational Journal of Developmental Neuroscience · 2019
Typereview
Languageen
FieldMedicine
TopicNeonatal and fetal brain pathology
Canadian institutionsUniversité de MontréalCanadian Apheresis GroupOntario Brain InstituteCentre Hospitalier Universitaire Sainte-Justine
FundersInstitute of Human Development, Child and Youth HealthCanadian Institutes of Health ResearchFondation Brain Canada
KeywordsWhite matterEtiologyMedicineNarrative reviewHyperintensityPathologyPediatricsMagnetic resonance imagingIntensive care medicineRadiology

Abstract

fetched live from OpenAlex

With increasing advances in the field of medical brain imaging, the known spectrum of white matter lesions has expanded, and we can now assess the presence of punctate white matter lesions (PWML). These focal small lesions are quite frequently detected in the preterm infant and in full-term infants with congenital heart malformations with, some studies reporting a link between these lesions and adverse long-term outcomes. The etiology of PWML has sparked a lot of questions over the years, some of which still remain unanswered. This narrative review will bring an overview of current knowledge and their significant clinical importance in the newborn brain.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.003
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0030.002
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.079
GPT teacher head0.369
Teacher spread0.290 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations20
Published2019
Admission routes2
Has abstractyes

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