Applications of Egg Yolk Antibody (IgY) in Diagnosis Reagents and in Prevention of Diseases
Bibliographic record
Abstract
This chapter begins with a brief discussion of the advantages of IgY compared to IgG before moving on to discuss the two main applications of IgY for human health. The first application is in diagnostics owing to IgY's binding specificity to given antigens: the use of IgY in immunological assays for clinical testing can eliminate the interference and false positives normally experienced when using mammalian IgG. In this section, we provide an overview of diagnostics and describe ABO blood typing and our work on the measurement of C-reactive protein and insulin using IgY. The second important use of IgY is in passive immunization therapy, wherein its ability to bind to specific antigens (pathogens, venoms, etc.) serves to neutralize their pathogenicity. Then, recent research on the therapeutic potential of IgY for the prevention of obesity and the treatment of celiac disease is introduced. Finally, monoclonal IgY antibodies and their applications are discussed. This chapter focusses on human health; related applications of IgY in the field of disease prevention and treatment in fish and domestic animals can be found elsewhere.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.017 | 0.013 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".