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A step-wise synthetic approach is necessary to access γ-conjugates of folate: folate-conjugated prodigiosenes
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.
The three-model screen
all 1,000 screened works →All three models called this out of scope.
stratum: aff_core · design weight: 5595.24 (the sample is stratified; any rate computed without the weight is wrong)
Claude Opus 4.8OUT
genre: empirical
about Canada: no
confidence: high
Synthetic chemistry paper on folate-conjugated prodigiosenes; the object is a synthetic route.
GPT-5.6 (high)OUT
genre: empirical
about Canada: no
confidence: high
The paper develops synthetic routes for folate conjugates rather than studying research practice.
Grok 4.5OUT
genre: empirical
about Canada: no
confidence: high
Synthetic organic chemistry of folate-conjugated prodigiosenes.
Abstract
Despite the vast literature that describes reacting folic acid with a pharmacophore, this route is ineffective in providing the correct regioisomer of the resulting conjugate.
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- RSC Advances
- Topic
- Microbial Metabolism and Applications
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- Dalhousie University
- Funders
- Canadian Institutes of Health ResearchQEII FoundationBreast Cancer Society of CanadaBeatrice Hunter Cancer Research InstituteTerry Fox FoundationNova Scotia Health Research FoundationCancer Research Institute
- Keywords
- ConjugatePharmacophoreConjugated systemChemistryFolic acidCombinatorial chemistryPolyethylene glycolFolate receptorEthylenediamineCarboxylic acidStereochemistryOrganic chemistryBiology
- Has abstract in OpenAlex
- yes