Pulmonary Hypertension Associated with Congenital Heart Disease: It's Not All the Same
Bibliographic record
Abstract
With improvements in medical and surgical therapeutics over the past two decades, the number of adults living with congenital heart disease now exceeds the number of children. Whether as a result of excessive pulmonary blood flow in childhood, or related to post-capillary obstruction, many of these adults have associated pulmonary hypertension (APAH-CHD) and require advanced management strategies. The evaluation of adults with APAH-CHD, which is often accompanied by complex cardiac lesions including single ventricle anatomy, can be extremely challenging. Presently, with the emergence of novel targeted PAH agents, medical-surgical approaches to APAH-CHD patients are rapidly evolving. In this edition of Advances, Guest Editor Dr Rich Krasuski calls upon authors to highlight the latest advances in the management of PAH in adults with structural heart disease. From the basics on anatomy for the non-congenital heart expert, to imaging, novel medical and interventional therapeutics, and the importance of transition programs, experts cover it all in this issue.On a personal note, this edition of Advances represents the final journal published during my term as Editor-in-Chief. I want to extend a tremendous thanks to the editorial board and to Deb McBride for their dedication and assistance during my term. It is with great pleasure that I am able to hand off the position to a close colleague and friend, Dr Myung Park. Dr Park's expertise in the field, and enthusiasm for helping the PH community, will undoubtedly serve her well in this new position as Editor-in-Chief. Congratulations, Myung!Finally, I want to express my deepest gratitude for the years of mentorship by Dr Robyn J. Barst who recently lost her own battle with illness, but won so many for the PH community. While many of us will miss her dearly, I am certain that Dr Robyn Barst's legacy will continue to impact the field for many years to come.Signing off,
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".