Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Full frame distilled prediction

Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

Candidate categories

none

Consensus categories

none

Domain

Candidate signal: noneConsensus signal: none

Study design

Candidate signal: Other designConsensus signal: none

Genre

Candidate signal: ReviewConsensus signal: Review

Teacher disagreement score

0.842

Threshold uncertainty score

0.381

Validation status

machine_predicted_unvalidated · codex-gemma-dda1882f352a

Codex and Gemma teacher scores by category

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Teacher spread

0.302 · how far apart the two teachers sit on this one work

Validation status

score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Importance: Both low and high gestational weight gain have been associated with adverse maternal and infant outcomes, but optimal gestational weight gain remains uncertain and not well defined for all prepregnancy weight ranges. Objectives: To examine the association of ranges of gestational weight gain with risk of adverse maternal and infant outcomes and estimate optimal gestational weight gain ranges across prepregnancy body mass index categories. Design, Setting, and Participants: Individual participant-level meta-analysis using data from 196 670 participants within 25 cohort studies from Europe and North America (main study sample). Optimal gestational weight gain ranges were estimated for each prepregnancy body mass index (BMI) category by selecting the range of gestational weight gain that was associated with lower risk for any adverse outcome. Individual participant-level data from 3505 participants within 4 separate hospital-based cohorts were used as a validation sample. Data were collected between 1989 and 2015. The final date of follow-up was December 2015. Exposures: Gestational weight gain. Main Outcomes and Measures: The main outcome termed any adverse outcome was defined as the presence of 1 or more of the following outcomes: preeclampsia, gestational hypertension, gestational diabetes, cesarean delivery, preterm birth, and small or large size for gestational age at birth. Results: Of the 196 670 women (median age, 30.0 years [quartile 1 and 3, 27.0 and 33.0 years] and 40 937 were white) included in the main sample, 7809 (4.0%) were categorized at baseline as underweight (BMI <18.5); 133 788 (68.0%), normal weight (BMI, 18.5-24.9); 38 828 (19.7%), overweight (BMI, 25.0-29.9); 11 992 (6.1%), obesity grade 1 (BMI, 30.0-34.9); 3284 (1.7%), obesity grade 2 (BMI, 35.0-39.9); and 969 (0.5%), obesity grade 3 (BMI, ≥40.0). Overall, any adverse outcome occurred in 37.2% (n = 73 161) of women, ranging from 34.7% (2706 of 7809) among women categorized as underweight to 61.1% (592 of 969) among women categorized as obesity grade 3. Optimal gestational weight gain ranges were 14.0 kg to less than 16.0 kg for women categorized as underweight; 10.0 kg to less than 18.0 kg for normal weight; 2.0 kg to less than 16.0 kg for overweight; 2.0 kg to less than 6.0 kg for obesity grade 1; weight loss or gain of 0 kg to less than 4.0 kg for obesity grade 2; and weight gain of 0 kg to less than 6.0 kg for obesity grade 3. These gestational weight gain ranges were associated with low to moderate discrimination between those with and those without adverse outcomes (range for area under the receiver operating characteristic curve, 0.55-0.76). Results for discriminative performance in the validation sample were similar to the corresponding results in the main study sample (range for area under the receiver operating characteristic curve, 0.51-0.79). Conclusions and Relevance: In this meta-analysis of pooled individual participant data from 25 cohort studies, the risk for adverse maternal and infant outcomes varied by gestational weight gain and across the range of prepregnancy weights. The estimates of optimal gestational weight gain may inform prenatal counseling; however, the optimal gestational weight gain ranges had limited predictive value for the outcomes assessed.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

The record

Venue

JAMA

Topic

Gestational Diabetes Research and Management

Field

Medicine

Canadian institutions

Centre Hospitalier Universitaire de SherbrookeUniversité de Sherbrooke

Funders

CHIST-ERANational Institute of Environmental Health SciencesNational Institute of Neurological Disorders and StrokeNational Institute of Diabetes and Digestive and Kidney DiseasesNorwegian Institute of Public HealthDet Sundhedsvidenskabelige Fakultet, Københavns UniversitetInstituto de Salud Carlos IIIFundação para a Ciência e a TecnologiaLeibniz-GemeinschaftMedical Research CouncilCenters for Disease Control and PreventionFogarty International CenterNational Institutes of HealthInstitut pour la Recherche en Santé PubliqueNovo Nordisk Foundation Center for Basic Metabolic ResearchRegione PiemonteMutuelle Générale de l'Education NationaleAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du TravailUniversité Paris-SudUniversidade do PortoRadboud Universitair Medisch CentrumNational Research FoundationNational Institute for Health and Care ResearchLastentautien TutkimussäätiöCompagnia di San PaoloAugustinus FondenUniversità degli Studi di TorinoU.S. Environmental Protection AgencyHelmholtz-Zentrum für UmweltforschungNovo NordiskJuho Vainion SäätiöDeutsche ForschungsgemeinschaftNederlandse Organisatie voor Wetenschappelijk OnderzoekUniversitat Pompeu FabraInstitut National de la Santé et de la Recherche MédicaleMinistero della SaluteNational Cancer InstituteLundbeckfondenCare and Public Health Research Institute, Universiteit MaastrichtEusko JaurlaritzaUniversitetet i BergenPäivikki ja Sakari Sohlbergin SäätiöTerveyden ja hyvinvoinnin laitosAcademy of FinlandUniversiteit MaastrichtErasmus Universiteit RotterdamSuomen KulttuurirahastoFaculty of Health and Medical Sciences, University of Western AustraliaLa Trobe UniversityZonMwTriodos FoundationMead Johnson NutritionWellcome TrustSyddansk UniversitetDanmarks GrundforskningsfondRadboud Institute for Health SciencesRijksuniversiteit GroningenGeneralitat de CatalunyaGeneralitat ValencianaFondation pour la Recherche MédicaleHelse- og OmsorgsdepartementetH. Lundbeck A/SEgmont FondenUniversity of BristolHelsingin YliopistoEuropean CommissionRadboud UniversiteitLudwig-Maximilians-Universität MünchenNorges ForskningsrådEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentDiabète QuébecHarokopio UniversityUniwersytet Jagielloński Collegium MedicumBritish Heart FoundationSundhed og Sygdom, Det Frie ForskningsrådHelmholtz Zentrum MünchenMarch of Dimes FoundationTurun YliopistoUniversiteit UtrechtCanadian Diabetes Association

Keywords

MedicineObstetricsAssociation (psychology)Weight gainGestationSmall for gestational ageGestational ageAdverse effectPregnancyBody weightInternal medicine

Has abstract in OpenAlex

yes

API

/api/v1/works/W2944634427