Synthesis of modified 1,5-imino-d-xylitols as ligands for lysosomal β-glucocerebrosidase
Bibliographic record
Abstract
Iminoalditols, also termed iminosugars, are natural occurring glycomimetics, in which the ring oxygen of the carbohydrate moiety is replaced by a trivalent basic nitrogen. Paradigmatic structural scaffolds are polyhydroxylated piperidines 1 , pyrrolidines 2 , indolizidines 3 , and pyrrolizidines 4 (Fig. 1 ) [ 1 , 2 , 3 , 4 , 5 ]. The nitrogen in the endocyclic position is responsible for the unique biological behavior of this compound class to interact and modulate active site specifically glycoside-processing enzymes. Since the last decades, such compounds have been of great interest for an interdisciplinary scientific community, including chemists, biochemists, as well as physicians.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.003 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".