Hippocampal-dependent memory retention is unaffected by a T21 light–dark cycle in female Fischer brown Norway rats
Bibliographic record
Abstract
The present study investigated circadian rhythms and hippocampal-dependent memory in female Fischer brown Norway rats. As in past reports with female Long Evans rats, we hypothesized that six days of exposure to an unentrainable T21 light–dark cycle that occurred during distributed Morris water task training would not impair the retention of the acquired memory. As expected, the rats did not have impaired retention of the place memory acquired in the distributed Morris water task. We next, quantified circadian entrainment two months after exposure to the T21 cycle. As expected, measures of circadian rhythms suggested that the rats exposed to the T21 had since entrained to a 12:12 light–dark cycle. To confirm that the T21 paradigm induces free-running circadian rhythms in female Fischer brown Norway rats, the control animals were subjected to the same T21 paradigm and circadian rhythms were continuously measured. Signs of free-running circadian rhythms were present during T21 exposure such as delayed phase of entrainment, elongated period, and decreased activity during the dark phase of the cycle. To our knowledge, this is one of the first characterization of activity rhythms in Fischer brown Norway rats.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.015 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".