The impact of spine sarcoma on mental health and well-being
Bibliographic record
Abstract
Spinal sarcomas are rare and often extremely debilitating, cases may involve multiple vertebrae, epidural space with spinal cord compression, adjacent solid organs, and the paraspinal musculature [ [1] Greenwood TJ Wallace A Friedman M V Hillen TJ Robinson CG Jennings JW Combined ablation and radiation therapy of spinal metastases: a novel multimodality treatment approach. Pain Physician. 2015; 18: 573-581 PubMed Google Scholar ]. Treatment is taxing, potentially requiring a multimodal approach involving surgery as well as radiation and/or chemotherapy, and there is a relatively high rate of disease recurrence [ 1 Greenwood TJ Wallace A Friedman M V Hillen TJ Robinson CG Jennings JW Combined ablation and radiation therapy of spinal metastases: a novel multimodality treatment approach. Pain Physician. 2015; 18: 573-581 PubMed Google Scholar , 2 Rao G Suki D Chakrabarti I Feiz-Erfan I Mody MG McCutcheon IE et al. Surgical management of primary and metastatic sarcoma of the mobile spine. J Neurosurg Spine. 2008; 9: 120-128https://doi.org/10.3171/SPI/2008/9/8/120 Crossref PubMed Scopus (53) Google Scholar ]. Surgical treatment of spine sarcoma usually requires a complete resection without physical breach of the tumor capsule to gain maximal local tumor control [ 3 Dekutoski M Osteosarcoma of the spine: prognostic variables for local recurrence and overall survival, a multicenter ambispective study. J Neurosurg. 2016; 25https://doi.org/10.3171/2015.11.SPINE15870 Google Scholar , 4 Amendola L Cappuccio M De Iure F Bandiera S Gasbarrini A Boriani S En bloc resections for primary spinal tumors in 20 years of experience: effectiveness and safety. Spine J. 2014; 14: 2608-2617https://doi.org/10.1016/j.spinee.2014.02.030 Abstract Full Text Full Text PDF PubMed Scopus (77) Google Scholar ]. To achieve this, the planned surgical morbidity might be very high, including functional nerve root ligation. Despite this, the tumor may return locally or with metastasis. Given its rarity, delays in diagnosis of spinal sarcoma are not uncommon and can lead to considerably poorer outcomes [ [5] Shah SA Saller J Evaluation and diagnosis of back pain in children and adolescents. J Am Acad Orthop Surg. 2016; 24: 37-45https://doi.org/10.5435/JAAOS-D-14-00130 Crossref PubMed Scopus (23) Google Scholar ]. This includes, but is not limited to, spinal cord injury, nerve root damage/sacrifice, and poorer prognosis [ [6] Varga PP Szövérfi Z Fisher CG Boriani S Gokaslan ZL Dekutoski MB et al. Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival. Eur Spine J. 2015; 24: 1092-1101https://doi.org/10.1007/s00586-014-3728-6 Crossref PubMed Scopus (81) Google Scholar ].
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".