123 Systemic hypertension in preterm infants - A population-based study
Bibliographic record
Abstract
Systemic hypertension (SH) has been reported in 0.2–3% of Neonatal Intensive Care Unit (NICU) patients. The epidemiology of the disease in preterm infants needs further exploration. To assess the incidence, temporal trend, risk factors, clinical characteristics, management and associated outcomes of preterm infants with SH. A retrospective population-based study including all infants born between January 2002 and December 2016 at < 31 weeks gestation in Nova Scotia. Patients diagnosed with SH (systolic blood pressure > 100mmHg requiring treatment, before discharge from NICU, or on 3 consecutive occasions during outpatient follow-up), were identified from the Provincial Perinatal Follow-up Database and patients’ charts. All SH patients were compared with matched controls (for gestational age, sex and birth weight). Perinatal data, details of SH and neonatal course were reviewed. Infants who died < 7 days of age were excluded. Out of 935 infants who met inclusion criteria, 109 (13.1%) had SH. Mean gestational age was 27.2 weeks (±1.9) and mean birth weight was 1039.3 g (±281.9) Table 1. Median post-menstrual age at diagnosis was 40 weeks Table 2. There was no significant difference in the temporal trend between the three study epochs (Figure 1). On logistic regression analysis, presence of major congenital anomaly was the only risk factor for SH (aOR 14.7, 95% CI:1.54, 141.2). Antenatal magnesium sulfate was protective (aOR 0.39, 95% CI: 0.20,0.75). 64 SH infants (59%) had nephrocalcinosis at time of diagnosis and the majority (79, 72.5%) were treated with ACE inhibitors. There was no significant difference in mortality (p=1.0) but the median length of stay was higher in the SH patients (p <0.01). Maternal, Delivery Room, and infantile characteristics for infants with HTN and matched controls BPD: bronchopulmonary dysplasia| PDA: patent ductus arteriosus| IVH: intraventricular hemorrhage| NEC: necrotizing enterocolitis| ROP: retinopathy of prematurity Clinical Data of infants with systemic hypertension ACE: angiotensin-converting-enzyme The incidence of SH in preterm infants < 31weeks gestation was 13.1% with no significant change in trend over the study years. Administration of antenatal magnesium sulfate was protective. More than half of SH patients had nephrocalcinosis. Patients with SH had longer hospital stay without increase in mortality.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".