234-LB: Incidence Trends of Diabetic Ketoacidosis at and after Diagnosis of Type 1 Diabetes in British Columbia, Canada
Bibliographic record
Abstract
Objective: Diabetic ketoacidosis (DKA) is a preventable complication in youth with type 1 diabetes (T1D). This study aimed to estimate the incidence trend of DKA at T1D diagnosis (DKA-AT, defined as DKA within 14 days of T1D diagnosis) and after T1D diagnosis (DKA-AFTER, defined as DKA after 14 days of T1D diagnosis) from 2002 to 2012 in British Columbia, Canada. Methods: We used a previously described population-based cohort of individuals diagnosed with T1D at <20 years of age. DKA episodes were identified using ICD9/10 codes (250.1X/E101X). Incidence rate ratio (IRR) was estimated using Poisson regression and trends in DKA rates were examined using Joinpoint regression analyses. Results: 2615 incident cases of T1D were identified between 2002 and 2012, of which 847 (32.4%) were diagnosed with DKA-AT. 52% were male. The rates of DKA-AT by year ranged between 24.1% (2008) and 37.3% (2006). No sex differences were observed. The IRR was 2.0 (95% CI: 1.6, 2.5; p<0.001) for those diagnosed with T1D at 0-4 years compared to those diagnosed at 15-19 years old, after adjusting for the trend by fiscal year. In the same period, 1886 episodes of DKA-AFTER were identified with a consistent increase from 5.3% (2002) to 9.5% (2012). The IRR for DKA-AFTER in children 0-4 years old at diabetes diagnosis was 9.13 (95% CI: 7.73, 10.77; p<0.001). After adjusting for the increasing trend by fiscal year, females had higher rates of DKA-AFTER than males (IRR 1.45, 95% CI: 1.33, 1.59; p<0.001). The average annual percent change for DKA-AFTER was 4.91% (95% CI: 2.69, 7.18; p<0.001). Conclusions: DKA-AT incidence remained unchanged while the incidence of DKA-AFTER increased over time, with the greatest burden in those diagnosed at a younger age. Targeted interventions are needed to raise public awareness to prevent DKA-AT and to educate patients and families in preventing DKA-AFTER. Disclosure K. Kao: None. N. Islam: None. D.A. Fox: None. S. Amed: None.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.003 | 0.005 |
| Science and technology studies | 0.002 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".