Ketene Chemistry after 100 Years: Ready for a New Century
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract The existence of ketenes was established 100 years ago, and in recent years the pace of discovery in the study of these reactive intermediates has accelerated — extremely unstable ketenes such as difluoroketene have been directly observed for the first time, while a variety of bisketenes stabilized by silyl substituents have been isolated as long‐lived compounds at room temperature. New methods for generating ketenes for applications in synthesis have been devised, and these have been applied in the preparation of many valuable targets. Asymmetric synthesis by nucleophilic additions and by [2+2] cycloadditions to ketenes to form β‐lactams and β‐lactones has been achieved with high yields and high stereoselectivities. The free‐radical chemistry of ketenes is receiving increasing levels of attention, and new rearrangement reactions of ketenes have been developed. These advances create new opportunities to utilize the unique structures and high reactivity of ketenes for even greater progress in the future. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.017 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it