Genome-wide association study identifies 30 loci associated with bipolar disorder
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Abstract
) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.
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The record
- Venue
- Nature Genetics
- Topic
- Genetic Associations and Epidemiology
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- McGill UniversityPublic Health OntarioMontreal Neurological Institute and HospitalDalhousie UniversityUniversity of TorontoCentre for Addiction and Mental HealthPrincess Margaret Cancer CentreMcGill University Health Centre
- Funders
- National Health and Medical Research CouncilCenter for Individualized Medicine, Mayo ClinicH. Lundbeck A/SMedical Research CouncilVetenskapsrådetNSW Ministry of HealthRheinische Friedrich-Wilhelms-Universität BonnNational Institute of Mental HealthAarhus UniversitetStockholms Läns LandstingEli Lilly and CompanyLundbeckfondenSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungWorld Health OrganizationWellcome TrustAgence Nationale de la RechercheGeneralitat de CatalunyaNational Institute for Health and Care ResearchEuropean Regional Development FundCentro de Investigación Biomédica en Red de Salud MentalDeutsche ForschungsgemeinschaftPfizerCanadian Institutes of Health ResearchNational Science Foundation
- Keywords
- BiologyGenome-wide association studyGeneticsBipolar disorderGenetic associationAssociation (psychology)GenomeComputational biologyEvolutionary biologySingle-nucleotide polymorphismGeneGenotypeNeuroscience
- Has abstract in OpenAlex
- yes