A Carbometallation-Intramolecular Cycloaddition Strategy for the AB-Taxane Ring and an Enone Accelerated Cope Rearrangement to Bicyclo[2.2.2]octanones
Why this work is in the frame
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Bibliographic record
Abstract
The one pot transformation of the magnesium chelates, derived from alkynyl alcohols, into tetraene-diols for the construction of substituted bicyclo[5.3.1]undecenes is described. This sequence affords a direct route to the AB-taxane ring system via a Lewis acid catalyzed intramolecular Diels-Alder reaction. The cycloaddition gives a single diastereomer due to the preferential formation of the Et2AlCl chelate. This adduct undergoes a facile enone accelerated Cope rearrangement to generate a substituted bicyclo[2.2.2]octanone. This isomerization fails below 110 °C when the ketone is absent.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it