Bibliographic record
Abstract
Neurogenesis – the generation of new neurons from a precursor population – has been documented as a normal or homeostatic process within various regions of the adult brain. In most instances, these precursors or endogenous neural stem/progenitor cells (NSPCs) reside in neurogenic zones located adjacent to the ventricular system. Across vertebrates, the distribution of NSPCs, and the capacity of homeostatic neurogenesis, varies greatly. Among mammals, NSPCs are restricted to only two constitutively active regions of the brain. In contrast, among teleost fish NSPCs, and constitutive neurogenesis, are widespread throughout the brain. Although less is known about reptiles, available evidence indicates that NSPCs are present within multiple continuously active regions. Here we investigate neurogenesis in an emerging amniote model of central nervous system regeneration, the leopard gecko. We have identified populations of NSPCs within various regions of the brain, including the ventricular zone (VZ) of the lateral ventricles. VZ cells of the lateral ventricle characteristically express the stem cell markers SOX2 and Musashi‐1. In addition, they share features in common with radial glia, including a lengthy radial process that contacts the pial surface, and the expression of the glial markers Vimentin and glial fibrillary associated protein. As evidenced by immunostaining for both proliferating cell nuclear antigen and phosphorylated histone H3, VZ cells of the lateral ventricles are mitotically active. Utilizing a bromodeoxyuridine (BrdU) pulse‐chase experiment, we labelled VZ cells for short‐term cell tracking. Immediately following the pulse period, BrdU+ cells were confined to the VZ. Following a 30‐day chase, we observed BrdU+ cells within the cellular layer of the cortex, a region dominated by mature neurons (immunopositive for the neuronal markers HuCD and NeuN). We conclude that the VZ of the lateral ventricles is a neurogenic zone, and provide compelling evidence of homeostatic neurogenesis in the leopard gecko brain. Support or Funding Information Natural Sciences and Engineering Research Council (NSERC) Discovery grant 400358
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".