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Record W2952646324 · doi:10.1093/bioinformatics/btx603

Segway 2.0: Gaussian mixture models and minibatch training

2017· article· en· W2952646324 on OpenAlexafffund
Rachel C.W. Chan, Maxwell W. Libbrecht, Eric G. Roberts, Jeffrey A. Bilmes, William Stafford Noble, Michael M. Hoffman

Bibliographic record

VenueBioinformatics · 2017
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBioinformatics and Genomic Networks
Canadian institutionsUniversity of TorontoPrincess Margaret Cancer CentreUniversity of British Columbia
FundersNational Human Genome Research InstituteCanadian Institutes of Health ResearchNational Institutes of HealthNatural Sciences and Engineering Research Council of CanadaUniversity Health Network
KeywordsComputer scienceScripting languageAnnotationSource codeGaussianMixture modelTraining setData miningCode (set theory)Artificial intelligenceMachine learningPattern recognition (psychology)Set (abstract data type)Programming language

Abstract

fetched live from OpenAlex

Summary: Segway performs semi-automated genome annotation, discovering joint patterns across multiple genomic signal datasets. We discuss a major new version of Segway and highlight its ability to model data with substantially greater accuracy. Major enhancements in Segway 2.0 include the ability to model data with a mixture of Gaussians, enabling capture of arbitrarily complex signal distributions, and minibatch training, leading to better learned parameters. Availability and implementation: Segway and its source code are freely available for download at http://segway.hoffmanlab.org. We have made available scripts (https://doi.org/10.5281/zenodo.802939) and datasets (https://doi.org/10.5281/zenodo.802906) for this paper's analysis. Contact: michael.hoffman@utoronto.ca. Supplementary information: Supplementary data are available at Bioinformatics online.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.010
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.072
Threshold uncertainty score0.241

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.010
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0020.003
Bibliometrics0.0010.002
Science and technology studies0.0010.001
Scholarly communication0.0020.003
Open science0.0070.003
Research integrity0.0030.005
Insufficient payload (model declined to judge)0.0720.042

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.250
Teacher spread0.226 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations49
Published2017
Admission routes2
Has abstractyes

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