Synthesis of `Molecular Asterisks' via Sequential Cross-Metathesis, Sonogashira and Cyclotrimerization Reactions
Bibliographic record
Abstract
All articles of this category A series of suitably functionalized C -linked carbohydrate derivatives 9 - 13 were prepared in good yields from alkenyl glycosides 1 - 4 by cross-metathesis reaction using Grubbs' catalyst [Cl 2 (PCy 3 ) 2 Ru=CHPh]. The reaction was also applied to 6- O -allyl ether 5 and N -Cbz allylamine 6 . C -Linked glycopeptide homologue 15 was prepared in 65% yield by cross-metathesis of perbenzylated β - C -allyl mannopyranoside 1 and allyl glycine derivative 8 . Finally, amine-ending C -glycoside 11 was subjected to a sequence of deprotection, amidation with p -iodobenzoic acid (EDC, HOBt, DIPEA, r.t., 12 h), Sonogashira reaction [Pd(PPh 3 ) 2 Cl 2 , Et 3 N, 65 °C, 6 h] and treatment with dicobalt octacarbonyl (60 °C, 6 h) to provide a `molecular asterisk' 21 in 53% yield. cross-metathesis - carbohydrates - glycopeptides - Sonogashira reaction - cyclotrimerization - ruthenium
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".