Hydroxypropylcellulose in Oral Drug Delivery
Bibliographic record
Abstract
Peroral drug administraion is by far the most common and most convenient route of drug delivery. The need of polymeric carriers permitting controlled release of a desired drug following oral administration has led to the screening of a large variety of synthetic and natural polymers. In oral solid dosage forms, hydroxypropylcellulose (HPC) is widely used as binder due to its excellent physico-chemical characteristics combined with mucoadhesive properties. Graft copolymers of HPC, decorated at random with short amphiphilic chains, form nanoparticles in water, consisting of a hydrophobic core surrounded by a hydrophilic, mucoadhesive shell. Such HPC-based assemblies can act as carrier of highly lipophilic drugs. The molecular design and characterization of HPC-based drug delivery systems are discussed, together with their ability to entrap cyclosporin A (CsA), and to carry it through model intestinal membrane.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".