Anti-inflammatory Effect and Cellular Uptake Mechanism of Peptides from Common Bean (<i>Phaseolus vulga</i> L.) Milk and Yogurts in Caco-2 Mono- and Caco-2/EA.hy926 Co-culture Models
Bibliographic record
Abstract
The bioavailability and anti-inflammatory activity of the phenolic compounds derived from gastrointestinal digestates of navy bean and light red kidney bean milks and yogurts were investigated in both Caco-2 mono- and Caco-2/EA.hy926 co-culture cell models. Instead of being transported directly, the ferulic acid ester derivatives in common bean milks and yogurts were found to be metabolized into ferulic acid and then be transported through the Caco-2 cell monolayer with an average basolateral ferulic acid concentration of 56 ± 3 ng/mL after 2 h. Strong anti-inflammatory effects were observed in the basolateral EA.hy926 cells of the co-culture model, and modulations of oxLDL-induced inflammatory mediators by the transported phenolics were verified to be through the p38 MAPK pathway. The present results suggest that the common bean-derived phenolics can be metabolized and absorbed by the intestinal epithelial cells and have antioxidant and anti-inflammatory effects against oxidative stress injury in vascular endothelial cells, hence contributing to the amelioration of vascular diseases.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".