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Record W2954510583 · doi:10.1016/s1474-4422(19)30141-3

Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial

2019· article· en· W2954510583 on OpenAlexaff
Johannes Levin, Sylvia Maaß, Madeleine Schuberth, Armin Giese, Wolfgang H. Oertel, Werner Poewe, Claudia Trenkwalder, Gregor K. Wenning, Ulrich Mansmann, Martin Südmeyer, Karla Eggert, Brit Mollenhauer, Axel Lipp, Matthias Löhle, Joseph Claßen, Alexander Münchau, Jan Kassubek, Florin Gandor, Daniela Berg, Silvia Egert-Schwender, Cornelia Eberhardt, Friedemann Paul, Kai Bötzel, Birgit Ertl‐Wagner, Hans‐Jürgen Huppertz, Ingrid Ricard, Günter U. Höglinger, Élisabeth André, Christiane Blankenstein, Monica Canelo, Marco Düring, Jens Ebentheuer, Christopher Fricke, Alexander L. Gerbes, Stefan Jun Groiss, Doreen Gruber, Christian J. Hartmann, Thomas Kirchner, Daniel Kroneberg, Martin Kunz, Stefan Lorenzl, Alexia Moldovan, Anna H. Noda, Heidi Pape, Gesine Respondek, Eva Schäffer, Martina Schneider, Alfons Schnitzler, Walter Schulz‐Schaeffer, Johannes Schwarz, Cornelia Skowronek, Alexander Storch, Vera Tadić, Dávid Vadász, Benno F. Zimmermann

Bibliographic record

VenueThe Lancet Neurology · 2019
Typearticle
Languageen
FieldMedicine
TopicParkinson's Disease Mechanisms and Treatments
Canadian institutionsUniversity of Toronto
FundersIpsenDeutsches Zentrum für Neurodegenerative ErkrankungenH. Lundbeck A/SDeutsche Stiftung NeurologieNOMIS StiftungRocheDeutsche ForschungsgemeinschaftDeutscher Akademischer AustauschdienstAbbVieEuropean CommissionNovartisParkinsonFonds DeutschlandBundesministerium für Bildung und ForschungDeutsche Parkinson VereinigungEuropean Parkinson’s Disease AssociationBischof Dr. Karl Golser StiftungTeva Pharmaceutical IndustriesDamp StiftungUCBArthur Arnstein StiftungHorizon 2020Actelion PharmaceuticalsBiogenMichael J. Fox Foundation for Parkinson's Research
KeywordsPlaceboDouble blindMedicineGallateRandomized controlled trialAtrophyEpigallocatechin gallateInternal medicinePharmacologyAlternative medicinePathologyChemistryAntioxidant

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.028

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.003
Meta-epidemiology (narrow)0.0030.001
Meta-epidemiology (broad)0.0070.004
Bibliometrics0.0010.001
Science and technology studies0.0010.002
Scholarly communication0.0020.002
Open science0.0010.001
Research integrity0.0040.004
Insufficient payload (model declined to judge)0.0080.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.270
Teacher spread0.244 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations126
Published2019
Admission routes1
Has abstractno

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