Chemical composition, antioxidant and cytotoxic activities of Onopordum acanthium L. crude oil and defatted metal
Bibliographic record
Abstract
In the present study, the seed oil from Onopordum acanthium. L and methanolic extract of the defatted meal were evaluated for their cytotoxic effect and antioxidant potential. The phenolic composition of the defatted meal was determined with RP-HPLC-UV and tocopherols levels in the crude oil were also assessed. Overall, the methanolic extract exhibited the best amount of total phenolics and flavonoids content (78.060.55 mg GAE/g on DW basis and 20.380.21 mg RE/g on DW basis, respectively).Seven phenolic compounds were identified with cinnamic acids as the major components (67.2%) and epicatechin was the dominant flavan-3-ol. Additionally, three individual tocopherols were determined and -tocopherol was the main isomer (914.80.02mg/kg). Data of antioxidant performance showed superior antioxidant capacity in methanol extract. Moreover methanolic extract from defatted seeds was more active towards HepG2 cancer cells than the crude oil(IC 50 of 44.053.54g/ml) and showed less cytotoxicity towards AML12 normal hepatocytes in comparison to doxorubicin indicating at least some tumor-specific action.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".