Обратное развитие сосудистой гипертрофии под действием блокады рецепторов ангиотензина II у пациентов с артериальной гипертензией
Why this work is in the frame
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Bibliographic record
Abstract
Aim. May blockade of the angiotensin II type 1 receptor (AT1) with an angiotensin receptor blocker reverse vascular pathology independent of blood pressure (BP) lowering. Material and methods. Stage I hypertensive, nondiabetic patients (61% male; age 38 to 67 years) were randomized after a 4-week washout period to olmesartan medoxomil 20 to 40 mg or atenolol 50 to 100 mg plus additional agents (hydrochlorothiazide, amlodipine, or hydralazine) as needed for a goal BP <140/90 mm Hg. At baseline and after 1 year of treatment, subcutaneous gluteal resistance arteries were examined on a pressurized myograph to evaluate remodeling. Biopsies were available from 22 atenolol recipients, 27 olmesartan medoxomil recipients, and 11 normal volunteer controls. Results. BP was reduced to a comparable degree by olmesartan medoxomil (from 149±11/92±8 mm Hg to 120±9/77±6 mm Hg; p<0,05 [mean ± standard deviation]) and atenolol (from 147±10/90±6 mm Hg to 125±12/78±7 mm Hg; p<0,05 [mean ± standard deviation]) from baseline for each arm (p=0,08 for the 40-week treatment mean between arms). After one year’s treatment, the wall-to-lumen ratio in arteries from patients treated with olmesartan medoxomil was significantly reduced (from 14,9% to 11,1%; p<0,01), whereas no significant change was observed in arteries from atenolol-treated patients (from 16,0% to 15,5%; p=NS); the wall- to-lumen ratio in controls was 11,0%. Conclusion. Blockade of AT1 receptors showed a superior corrective effect on the altered structure of resistance arteries in essential hypertension that was independent of the magnitude of BP reduction, and resulted in values similar to those in normotensive controls.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.006 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it