Impairments In Lower Limb Microvascular Function Associated With Cycle Phases In Young Healthy Women.
Bibliographic record
Abstract
Impairments in lower limb microvascular function associated with cycle phases in young healthy women. Rogerio N Soares, Anmol T Mattu, Juan M Murias. University of Calgary, Faculty of Kinesiology. PURPOSE: Differences in women’s hormone concentrations throughout the menstrual cycle affects vascular responsiveness. Previous investigations have shown that these changes can be modulated by regular use of oral contraceptives. However, most of these studies only assessed changes in vascular function at the upper limb conduit artery level. This study investigated whether vascular function at the lower limb microvasculature of healthy young women might be affected by the phase of the menstrual cycle. METHODS: 14 young (25 ± 5 years of age) physically active women participated in the study. The participants were assigned to two groups of seven participants each according to oral contraceptive use: non-contraceptive group (women who did not use any contraceptive within the last two years prior to the intervention - NCP) and oral contraceptive group (seven women who used oral contraceptive regularly for at least two years prior to the intervention – OCP). The participants underwent two lower limb vascular occlusion tests (5 min of baseline, 5 min of occlusion, and 8 min following cuff release) in two different phases of the menstrual cycle (follicular and luteal phase). Microvascular responsiveness was assessed by the percent of change of the NIRS-derived muscle oxygen saturation (StO2) reperfusion slope (%/sec) of the tibialis anterior muscle. RESULTS: There was no difference in the reperfusion slope of the NCP group between the follicular (1.18 ± 0.5 %/sec) and luteal (1.01 ± 0.3 %/sec) phases. The reperfusion slope of the OCP group was significantly steeper in the follicular (0.85 ± 0.2 %/sec) compared to the luteal phase (0.63 ± 0.2 %/sec). CONCLUSION: Use of oral contraceptive is associated with reduced microvascular function in the luteal phase in young physically active women.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".