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Record W2962697832 · doi:10.1002/cpa.21651

Systematic Measures of Biological Networks II: Degeneracy, Complexity, and Robustness

2016· article· en· W2962697832 on OpenAlexaff
Yao Li, Yingfei Yi

Bibliographic record

VenueCommunications on Pure and Applied Mathematics · 2016
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGene Regulatory Network Analysis
Canadian institutionsUniversity of Alberta
Fundersnot available
KeywordsRobustness (evolution)Degeneracy (biology)MathematicsAttractorOrdinary differential equationStatistical physicsEntropy (arrow of time)Applied mathematicsTheoretical computer scienceComputer scienceDifferential equationMathematical analysis

Abstract

fetched live from OpenAlex

Abstract This paper is part II of a two‐part series devoted to the study of systematic measures in a complex bionetwork modeled by a system of ordinary differential equations. In this part, we quantify several systematic measures of a biological network including degeneracy, complexity, and robustness. We will apply the theory of stochastic differential equations to define degeneracy and complexity for a bionetwork. Robustness of the network will be defined according to the strength of attractions to the global attractor. Based on the study of stationary probability measures and entropy made in part I of this series, we will investigate some fundamental properties of these systematic measures, in particular the connections between degeneracy, complexity, and robustness.© 2016 Wiley Periodicals, Inc.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.008
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.003
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.008
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.001
Science and technology studies0.0000.003
Scholarly communication0.0020.003
Open science0.0010.002
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.061
GPT teacher head0.268
Teacher spread0.208 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations9
Published2016
Admission routes1
Has abstractyes

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