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Record W2962780088 · doi:10.1101/715649

Genetic and environmental canalization are not associated among altitudinally varying populations of <i>Drosophila melanogaster</i>

2019· preprint· en· W2962780088 on OpenAlexaff
Maria Pesevski, Ian Dworkin

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2019
Typepreprint
Languageen
FieldEnvironmental Science
TopicPhysiological and biochemical adaptations
Canadian institutionsMcMaster University
Fundersnot available
KeywordsBiologyDrosophila melanogasterEvolutionary biologyWingGenetic variationPopulationGeneticsPopulation geneticsEcology

Abstract

fetched live from OpenAlex

Abstract Organisms are exposed to environmental and mutational effects influencing both mean and variance of phenotypes. Potentially deleterious effects arising from this variation can be reduced by the evolution of buffering (canalizing) mechanisms, ultimately reducing phenotypic variability. As such, there has been interest regarding the plausible conditions that enable canalizing mechanisms to evolve. Under some models, the circumstances under which genetic canalization evolves is limited, despite apparent empirical evidence for it. It has been argued that canalizing mechanisms for mutational effects may evolve as a correlated response to environmental canalization (the congruence model). Yet, empirical evidence has not consistently supported the prediction of a correlation between genetic and environmental canalization. In a recent study, a population of Drosophila melanogaster adapted to high altitude showed evidence of genetic decanalization relative to those from low-altitudes. Using strains derived from these populations, we tested if they also varied for environmental canalization, rearing them at different temperatures. Using wing morphology, we quantified size, shape, cell (trichome) density and frequencies of mutational defects. We observed the expected differences in wing size and shape, cell density and mutational defects between the high- and low-altitude populations. However, we observed little evidence for a relationship between a number of measures of environmental canalization with population or with visible defect frequency. Our results do not support the predicted association between genetic and environmental canalization.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.018
GPT teacher head0.197
Teacher spread0.180 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2019
Admission routes1
Has abstractyes

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