Chronic Ongoing Stressors and C-Reactive Protein: A Within-Person Study
Bibliographic record
Abstract
Objectives: Literature suggests C-reactive protein (CRP)—as a marker of low-grade systemic inflammation—may mediate the linkage between chronic stressors and cardiometabolic conditions. Previous population-based reports are based on weak methodologies and may have yielded incorrect inferences. The current study examined linkages of within-person CRP variation with corresponding variation in stressor burdens. Method: Data were from the 2006, 2010, and 2014 waves of the U.S. Health and Retirement Study. Analysis was through unit fixed effects and first-difference estimators. Both gender-combined and gender-specific models were run. Results: In none of the analyses was CRP positively associated with chronic stressors. This was true among both genders, and in models of linear as well as nonlinear change. Results held in a series of separate robustness checks. Discussion: CRP may not mediate the social etiology of degenerative diseases. Population representative evidence of inflammation’s role in these processes remains absent.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".