SYNTHESIS OF 6BROMOOXO QUINAZOLINE DERIVATIVES AND THEIR HARAMCOLOGICAL ACTIVITIES
Bibliographic record
Abstract
A number of substituted oxoquinazolines are known for their pharmacological importance like anti‐analgesic, anti‐inflammatory, and anti‐bacterial activity. In the present investigation is carried out for the synthesis of 2‐(6‐bromo‐2‐phenyl‐4‐oxoquinazolin‐3(4H)‐yl)‐N‐substituted acetamides to carry out their pharmacological activities. A number of oxoquinazoline derivatives have been synthesized, purified and characterized with the help of their analytical and spectral data (IR, NMR & Mass).The required ethyl [6‐bromo‐2‐phenyl‐4‐oxoquinazolin‐3(4H)‐yl]acetate has been synthesized from 6‐bromo‐2‐phenyl‐1,3,4‐benzoxazinone and ethyl glycinate. By the use of corresponding primary amines the N‐substituted acetamides were prepared. The synthesized compounds were screened for their anti‐bacterial activity, anti‐inflammatory activity and analgesic activity by standard methods. The compound shows Pharmacological activities in comparison with the standard.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".