Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- none
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: Bench or experimentalConsensus signal: Bench or experimental
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.010
- Threshold uncertainty score
- 0.380
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.238 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
The record
- Venue
- Cancer Cell
- Topic
- Cancer-related gene regulation
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- Princess Margaret Cancer CentreStructural Genomics ConsortiumOntario Institute for Cancer ResearchUniversity of Toronto
- Funders
- Eshelman Institute for Innovation, University of North Carolina at Chapel HillJanssen PharmaceuticalsNational Institute of General Medical SciencesNational Medical Research CouncilInnovative Medicines InitiativeFondazione Umberto VeronesiCancer Science Institute of Singapore, National University of SingaporeNational Research Foundation of KoreaMinistry of Education - SingaporeNational Research Foundation SingaporeMinistero della SaluteCanada Foundation for InnovationMerckOntario Ministry of Economic Development and InnovationCycle for SurvivalPershing Square FoundationNational Cancer InstituteCollege of Natural Resources, University of California BerkeleyNational Heart, Lung, and Blood InstituteEdward P. Evans FoundationAssociazione Italiana per la Ricerca sul CancroGenome CanadaFundação de Amparo à Pesquisa do Estado de São PauloAstraZenecaEuropean Hematology AssociationStarr FoundationNational Institutes of HealthLeukemia and Lymphoma Society of CanadaPfizerAmerican Glaucoma SocietyTakeda Pharmaceuticals U.S.A.Leukemia and Lymphoma SocietyAmgenBoehringer IngelheimNational University of SingaporeNovartis PharmaAbbVieHenry and Marilyn Taub FoundationWellcome TrustAstellas Pharma US
- Keywords
- MethylationArginineRNA splicingRNAChemistryRNA-binding proteinCancer researchAlternative splicingCell biologyComputational biologyBiochemistryBiologyMessenger RNAAmino acidGene
- Has abstract in OpenAlex
- no