Les protéines antisens des virus HTLV
Bibliographic record
Abstract
Les virus T-lymphotropiques humains (HTLV) sont composs de quatre membres : HTLV-1, 2, 3 et 4. Issus d'une transmission de virus simiens, les virus HTLV sont capables d'infecter plusieurs types de cellules du systme immunitaire. HTLV-1 est le premier rtrovirus humain isol responsable de pathologies chez l'individu infect. Bien que l'expression des gnes des rtrovirus dpende gnralement du promoteur situ dans leur LTR 5 , il a t dmontr que le LTR 3'des HTLV possdait aussi une activit promotrice responsable de la production d'un transcrit antisens in vivo. Ces transcrits sont capables de produire des protines dites antisens, nommes HBZ, APH-2, APH-3 et APH-4, respectivement pour HTLV-1, 2, 3 et 4. La transcription antisens chez HTLV-1 a t analyse en dtail et la protine HBZ est la plus tudie des quatre protines antisens. Il est aujourd'hui avr qu'elle possde des rles importants pour la rplication virale et le dveloppement de la leucmie. Peu d'tudes ont cependant t ralises sur la transcription antisens chez HTLV-2 et encore moins chez HTLV-3/4, bien qu'il semble trs probable que la transcription antisens joue galement un rle crucial dans leur processus infectieux.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.007 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.008 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".