L'ideologie monarchique dans les chartes de la dynastie serbe des Némanides (1168-1371): Étude diplomatique
Bibliographic record
Abstract
Glucocorticoids are critical regulators of the cellular processes that allow animals to cope with stressors. In teleosts, cortisol is the primary circulating glucocorticoid and this hormone mediates a suite of physiological responses, most importantly energy substrate mobilization that is essential for acute stress adaptation. Cortisol signaling has been extensively studied and the majority of work has been on the activation of the glucocorticoid receptor (GR), a ligand-bound transcription factor, and the associated downstream transcriptional and protein responses. Despite the role of this hormone in acute stress adaptation, very few studies have examined the rapid effects of this hormone on cellular function. The nongenomic corticosteroid effects, which are rapid (seconds to minutes) and independent of transcription and translation, involve changes to second-messenger pathways and effector proteins, but the primary receptors involved in this pathway activation remain elusive. In teleosts, a few studies suggested the possibility that GR located on the membrane may be initiating a rapid response based on the abrogation of this effect with RU486, a GR antagonist. However, studies have also proposed other signaling mechanisms, including a putative novel membrane receptor and changes to membrane biophysical properties as initiators of rapid signaling in response to cortisol stimulation. Emerging evidence suggests that cortisol activates multiple signaling pathways in cells to bring about rapid effects, but the underlying physiological implications on acute stress adaptation are far from clear.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".