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Record W2968662162 · doi:10.1016/s2352-3026(19)30161-9

Bodyweight-adjusted rivaroxaban for children with venous thromboembolism (EINSTEIN-Jr): results from three multicentre, single-arm, phase 2 studies

2019· article· en· W2968662162 on OpenAlexaff
Paul Monagle, Anthonie W.A. Lensing, Kirstin Thelen, Ida Martinelli, Christoph Male, Amparo Santamaría, Elena Samochatova, Riten Kumar, Susanne Holzhauer, Paola Saracco, Paolo Simioni, Jeremy Robertson, Gernot Grangl, Phillip Connor, Guy Young, Angelo Claudio Molinari, Ulrike Nowak‐Göttl, Gili Kenet, Stefanie Kapsa, Stefan Willmann, Ákos F. Pap, Michael Becka, Teresa Twomey, Jan Beyer‐Westendorf, Martin H. Prins, Dagmar Kubitza, Werner Streif, Jorge Carniero, Sandra Logetto, Leonardo R. Brandão, Pascal Amédro, Damien Bonnet, Sven Dietrich, Krisztián Kállay, Shoshana Revel‐Vilk, Hannah Tamary, Paola Giordano, Maria Abbattista, Andrea Artoni, Daniela Tormene, Hiroshi Ono, Maroeska WM Te Loo, C. Heleen van Ommen, Margreet A. Veening, Monique H Suiker, Marjolein Peters, Anastasia Shamardina, Nizhny Novgorod, Lyudmila Zubarovskaya, María Ángeles Dasí, María Dolores Elorza, Manuel Sánchez Luna, Manuela Albisetti, Sebastian Grunt, Kaan Kavaklı, Tina Biss, Philip Connor, Mike Williams, Suchitra Acharya, Rumi Bhat, Susan Kearney, Kavita Patel, Madvi Rajpukar, Jeffrey H. Schwartz, Terry A. Vik, Tung Wynn, Donald L. Yee

Bibliographic record

VenueThe Lancet Haematology · 2019
Typearticle
Languageen
FieldMedicine
TopicBlood Coagulation and Thrombosis Mechanisms
Canadian institutionsChildren's Hospital of Eastern OntarioUniversity of Ottawa
FundersJanssen Research and Development
KeywordsMedicineRivaroxabanFondaparinuxVitamin K antagonistRegimenDosingPediatricsVenous thrombosisSurgeryVenous thromboembolismInternal medicineWarfarinThrombosis

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Non-randomized trial · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.024

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.004
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0040.005
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.081
GPT teacher head0.325
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNon-randomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations77
Published2019
Admission routes1
Has abstractno

Explore more

Same venueThe Lancet HaematologySame topicBlood Coagulation and Thrombosis MechanismsFrench-language works237,207