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Record W2968662162 · doi:10.1016/s2352-3026(19)30161-9

Bodyweight-adjusted rivaroxaban for children with venous thromboembolism (EINSTEIN-Jr): results from three multicentre, single-arm, phase 2 studies

2019· article· en· W2968662162 on OpenAlex
Paul Monagle, Anthonie W.A. Lensing, Kirstin Thelen, Ida Martinelli, Christoph Male, Amparo Santamaría, Elena Samochatova, Riten Kumar, Susanne Holzhauer, Paola Saracco, Paolo Simioni, Jeremy Robertson, Gernot Grangl, Phillip Connor, Guy Young, Angelo Claudio Molinari, Ulrike Nowak‐Göttl, Gili Kenet, Stefanie Kapsa, Stefan Willmann, Ákos F. Pap, Michael Becka, Teresa Twomey, Jan Beyer‐Westendorf, Martin H. Prins, Dagmar Kubitza, Werner Streif, Jorge Carniero, Sandra Logetto, Leonardo R. Brandão, Pascal Amédro, Damien Bonnet, Sven Dietrich, Krisztián Kállay, Shoshana Revel‐Vilk, Hannah Tamary, Paola Giordano, Maria Abbattista, Andrea Artoni, Daniela Tormene, Hiroshi Ono, Maroeska WM Te Loo, C. Heleen van Ommen, Margreet A. Veening, Monique H Suiker, Marjolein Peters, Anastasia Shamardina, Nizhny Novgorod, Lyudmila Zubarovskaya, María Ángeles Dasí, María Dolores Elorza, Manuel Sánchez Luna, Manuela Albisetti, Sebastian Grunt, Kaan Kavaklı, Tina Biss, Philip Connor, Mike Williams, Suchitra Acharya, Rumi Bhat, Susan Kearney, Kavita Patel, Madvi Rajpukar, Jeffrey H. Schwartz, Terry A. Vik, Tung Wynn, Donald L. Yee

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueThe Lancet Haematology · 2019
Typearticle
Languageen
FieldMedicine
TopicBlood Coagulation and Thrombosis Mechanisms
Canadian institutionsChildren's Hospital of Eastern OntarioUniversity of Ottawa
FundersJanssen Research and Development
KeywordsMedicineRivaroxabanFondaparinuxVitamin K antagonistRegimenDosingPediatricsVenous thrombosisSurgeryVenous thromboembolismInternal medicineWarfarinThrombosis

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.310
Threshold uncertainty score0.879

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.081
GPT teacher head0.325
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it