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Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. Kunkle, Benjamin Grenier‐Boley, Rebecca Sims, Joshua C. Bis, Vincent Damotte, Adam C. Naj, Anne Boland, Maria Vronskaya, Sven J. van der Lee, Alexandre Amlie‐Wolf, Céline Bellenguez, Aura Frizatti, Vincent Chouraki, Eden R. Martin, Kristel Sleegers, Nandini Badarinarayan, Jóhanna Jakobsdóttir, Kara L. Hamilton‐Nelson, Sonia Moreno–Grau, Robert Olaso, Rachel Raybould, Yuning Chen, Amanda Kuzma, Mikko Hiltunen, Taniesha Morgan, Shahzad Ahmad, Badri N. Vardarajan, Jacques Epelbaum, Per Hoffmann, Merçé Boada, Gary W. Beecham, Jean-Guillaume Garnier, Denise Harold, Annette L. Fitzpatrick, Otto Valladares, Marie-Laure Moutet, Amy Gerrish, Albert V. Smith, Liming Qu, Delphine Bacq, Nicola Denning, Xueqiu Jian, Yi Zhao, Maria Del Zompo, Nick C. Fox, Seung‐Hoan Choi, Ignacio Mateo, Joseph T. Hughes, Hieab H.H. Adams, John Malamon, Florentino Sánchez-García, Yogen Patel, Jennifer A. Brody, Beth A. Dombroski, María Cándida Déniz Naranjo, Makrina Daniilidou, Gudny Eiriksdottir, Shubhabrata Mukherjee, David Wallon, James Uphill, Thor Aspelund, Laura B. Cantwell, Fabienne Garzia, Daniela Galimberti, Edith Hofer, Mariusz Butkiewicz, Bertrand Fin, Elio Scarpini, Chloé Sarnowski, William S. Bush, Stéphane Meslage, Johannes Kornhuber, Charles C. White, Robert C. Barber, Sebastiaan Engelborghs, Sabrina Sordon, Dina Voijnovic, Perrie M. Adams, Rik Vandenberghe, Manuel Mayhaus, L. Adrienne Cupples, Marilyn S. Albert, Peter Paul De Deyn, Wei Gu, J.J. Himali, Duane Beekly, Alessio Squassina, Annette M. Hartmann, Adelina Orellana, Deborah Blacker, Eloy Rodríguez‐Rodríguez, Simon Lovestone, Melissa E. Garcia, Rachelle S. Doody, Carmen Munoz-Fernadez, Rebecca Sussams, Honghuang Lin, Thomas Fairchild, Clive Holmes, Hata Karamujić‐Čomić, Matthew P. Frosch, Håkan Thonberg, Wolfgang Maier, Gennady V. Roshchupkin, Bernardino Ghetti, Vilmantas Giedraitis, Amit Kawalia, Shuo Li, Ryan M. Huebinger, Lena Kilander, Susanne Moebus, Isabel Hernández, M. Ilyas Kamboh, RoseMarie Brundin, James Turton, Qiong Yang, Mindy J. Katz, Letizia Concari, Jenny Lord, Alexa S. Beiser, C. Dirk Keene, Seppo Helisalmi, Iwona Kłoszewska, Walter A. Kukull, Anne M. Koivisto, Aoibhinn Lynch, Lluís Tárraga, Eric B. Larson, Annakaisa Haapasalo, Brian Lawlor, Richard B. Lipton, Vincenzo Solfrizzi, Michael Gill, W. T. Longstreth, Thomas J. Montine, Vincenza Frisardi, Mónica Díez-Fairén, Fernando Rivadeneira, Ronald C. Petersen, Vincent Deramecourt, Ignacio Álvarez, Francesca Salani, Antonio Ciaramella, Eric Boerwinkle, Eric M. Reiman, Nathalie Fiévet, Jerome I. Rotter, Joan Reisch, Olivier Hanon, Chiara Cupidi, André G. Uitterlinden, Donald R. Royall, Carole Dufouil, Raffaele Maletta, Itziar de Rojas, Mary Sano, Alexis Brice, Roberta Cecchetti, Peter St George‐Hyslop, Karen Ritchie, Magda Tsolaki, Debby W. Tsuang, Bruno Dubois, David Craig, Chuang‐Kuo Wu, Hilkka Soininen, Despoina Avramidou, Roger L. Albin, Laura Fratiglioni, Antonia Germanou, Liana G. Apostolova, Lina Keller, Maria Koutroumani, Steven E. Arnold, Francesco Panza, Olymbia Gkatzima, Sanjay Asthana, Didier Hannequin, Patrice L. Whitehead, Craig Atwood, Paolo Caffarra, Harald Hampel, Inés Quintela, Ãngel Carracedo, Lars Lannfelt, David C. Rubinsztein, Lisa L. Barnes, Florence Pasquier, Lutz Frölich, Sandra Barral, Bernadette McGuinness, Thomas G. Beach, Janet Johnston, James T. Becker, Peter Passmore, Eileen H. Bigio, Jonathan M. Schott, Thomas D. Bird, Jason D. Warren, Bradley F. Boeve, Michelle K. Lupton, James D. Bowen, Adam Boxer, John Powell, James R. Burke, John Kauwe, Jeffrey M. Burns, Michelangelo Mancuso, Joseph D. Buxbaum, Ubaldo Bonuccelli, Nigel J. Cairns, Andrew McQuillin, Chuanhai Cao, Gill Livingston, Chris Carlson, Nicholas Bass, Cynthia M. Carlsson, John Hardy, Regina M. Carney, José Brás, Minerva M. Carrasquillo, Rita Guerreiro, Mariet Allen, Helena C. Chui, Elizabeth Fisher, Carlo Masullo, Elizabeth Crocco, Charles DeCarli, Gina Bisceglio, Malcolm Dick, Li Ma, Ranjan Duara, Caroline Graff, Denis A. Evans, Angela Hodges, Kelley M. Faber, Martin Scherer, Kenneth B. Fallon, David W. Fardo, Reinhard Heun, Martin R. Farlow, Heike Kölsch, Steven H. Ferris, Markus Leber, Tatiana M. Foroud, Isabella Heuser, Douglas Galasko, Ina Giegling, Marla Gearing, Michael Hüll, Daniel H. Geschwind, John R. Gilbert, John C. Morris, Robert C. Green, Kevin H. Mayo, John H. Growdon, Thomas Feulner, Ronald L. Hamilton, Lindy E. Harrell, Dmitriy Drichel, Lawrence S. Honig, Thomas D. Cushion, Matthew J. Huentelman, Paul Hollingworth, Christine M. Hulette, Bradley T. Hyman, Iain Marshall, Gail P. Jarvik, Alun Meggy, Erin L. Abner, Georgina Menzies, Lee‐Way Jin, Ganna Leonenko, Luís Miguel Real, Gyungah R Jun, Clinton T. Baldwin, Detelina Grozeva, Anna Karydas, Giancarlo Russo, Ronald Kim, Frank Jessen, Neil W. Kowall, Bruno Vellas, Joel H. Kramer, Emma Vardy, Frank M. LaFerla, Karl‐Heinz Jöckel, James J. Lah, Martin Dichgans, James B. Leverenz, David Mann, Allan I. Levey, Stuart Pickering‐Brown, Andrew P. Lieberman, Norman Klopp, Kathryn L. Lunetta, H‐Erich Wichmann, Constantine G. Lyketsos, Kevin Morgan, Daniel Marson, Kristelle Brown, Frank Martiniuk, Christopher Medway, Deborah C. Mash, Markus M. Nöthen, Eliezer Masliah, Nigel M. Hooper, Wayne C. McCormick, Antonio Daniele, Susan M. McCurry, Andrew McDavid, John Gallacher, Ann C. McKee, Hendrik van den Bussche, Marsel Mesulam, Carol Brayne, Bruce L. Miller, Steffi G. Riedel‐Heller, Carol A. Miller, Joshua W. Miller, Ammar Al‐Chalabi, Christopher E. Shaw, Amanda Myers, Jens Wiltfang, John Olichney, Victoria Álvarez, Joseph E. Parisi, Andrew B. Singleton, Henry L. Paulson, John Collinge, William Perry, Simon Mead, Elaine R. Peskind, David H. Cribbs, Martin N. Rossor, Aimee Pierce, Natalie S. Ryan, Wayne W. Poon, Benedetta Nacmias, Huntington Potter, Sandro Sorbi, Joseph F. Quinn, Eleonora Sacchinelli, Ashok Raj, Gianfranco Spalletta, Murray A. Raskind, Carlo Caltagirone, Paola Bossù, Maria Donata Orfei, Barry Reisberg, Robert Clarke, Christiane Reitz, A. David Smith, John M. Ringman, Donald Warden, Erik D. Roberson, Gordon Wilcock, Ekaterina Rogaeva, Amalia C. Bruni, Howard J. Rosen, Maura Gallo, Roger N. Rosenberg, Yoav Ben‐Shlomo, Mark A. Sager, Patrizia Mecocci, Andrew J. Saykin, Pau Pástor, Michael L. Cuccaro, Jeffery M. Vance, Julie A. Schneider, Lori S. Schneider, Susan Slifer, William W. Seeley, Amanda Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Russell H. Swerdlow, Mitchell Tang, Rudolph E. Tanzi, John Q. Trojanowski, Juan C. Troncoso, Vivianna M. Van Deerlin, Linda J. Van Eldik, Harry V. Vinters, Jean Paul Vonsattel, Sandra Weıntraub, Kathleen A. Welsh‐Bohmer, Kirk C. Wilhelmsen, Jennifer Williamson, Thomas S. Wingo, Randall L. Woltjer, Clinton B. Wright, Chang‐En Yu, Lei Yu, Yasaman Saba, Alberto Pilotto, María J. Bullido, Oliver Peters, Paul K. Crane, David A. Bennett, Paola Bosco, Eliécer Coto, Virginia Boccardi, Phil L. De Jager, Alberto Lleó, Oscar L. López, Martin Ingelsson, Panos Deloukas, Carlos Cruchaga, Rhian Gwilliam, Myriam Fornage, Alison Goate, Pascual Sánchez‐Juan, Patrick G. Kehoe, Najaf Amin, Claudine Berr, Stéphanie Debette, Seth Love, Lenore J. Launer, Steven G. Younkin, Jean‐François Dartigues, Chris Corcoran, M. Arfan Ikram, Dennis W. Dickson, Gaël Nicolas, Dominique Campion, JoAnn T. Tschanz, Helena Schmidt, Håkon Håkonarson, Jordi Clarimón, Ron Munger, Reinhold Schmidt, Lindsay A. Farrer, Christine Van Broeckhoven, Anita L. DeStefano, Lesley Jones, Jonathan L. Haines, Jean‐François Deleuze, Michael J. Owen, Vilmundur Guðnason, Richard Mayeux, Valentina Escott‐Price, Bruce M. Psaty, Alfredo Ramı́rez, Li‐San Wang, Agustı́n Ruiz, Cornelia M. van Duijn, Peter Holmans, Sudha Seshadri, Julie Williams, Philippe Amouyel, Gerard D. Schellenberg, Jean‐Charles Lambert, Margaret A. Pericak‐Vance
Bibliographic record
VenueNature Genetics · 2019
Typeerratum
Languageen
FieldMedicine
TopicAlzheimer's disease research and treatments
Canadian institutionsOccupational Cancer Research CentreUniversity of Toronto
FundersNational Institute on AgingAvid RadiopharmaceuticalsAllerganNational Institutes of HealthGenentechGrifolsH. Lundbeck A/SServierParkinson's UKEisaiWellcome TrustAgence Nationale de la RechercheRosetrees TrustNational Institute for Health and Care ResearchMedical Research CouncilBiogenAmgenPfizerEli Lilly and CompanyOtsuka Pharmaceutical
KeywordsBiologyDiseaseMeta-analysisImmunityComputational biologyGeneticsGenealogyEvolutionary biologyInternal medicineImmune systemHistory
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: Meta-analysis
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.901
Threshold uncertainty score1.000
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.048
GPT teacher head0.353
Teacher spread0.305 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
Study designMeta-analysis
Domainnot available
GenreReview
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations91
Published2019
Admission routes1
Has abstractno